Anavex Life Sciences Corp (AVXL)

[falconer66a]

Ah, blarcamesine has already been tested.

Thank you very much for this information, showing that early tests of blarcamesine (Anavex 2-73) have already been conducted on ALS animal models, successfully.

My conjecture is now a bit more firm. If I had ALS I'd be petitioning an ALS support association to encourage and underwrite human trials. But I have a different CNS disease, hereditary spastic paraplegia (HSP), making my legs stiff. Have to use a walker to amble about.

In that regard (HSP) I noted that the girls with Rett, in the first safety and tolerability trials of blarcamesine, showed that one outcome of blarcamesine therapy (even at low doses) was the markedly increased production of GABA, gamma-aminobutyric acid. GABA is deficient in the long motor neurons that control the muscles in my legs, allowing the nerves to continually fire; causing the spasticity. I'm so eager to participate in a clinical trial of blarcamesine for those of us with HSP. I'm certain that it will be therapeutic.

But before I petition the HSP support group, I'll wait for the results from the full Rett clinical trial. Those results will reveal the improved GABA factor. Everyone who understands the GABA-deficient pathology of HSP will instantly desire to start taking or allow blarcamesine. HSP is one of a number of hidden rare diseases for which blarcamesine will be profoundly therapeutic.