NorthWest Biotherapeutics Inc (NWBO)

[MI Dendream]

Think about this, Flipper or Senti or Doc, I can’t remember who because they is no voice told me there, is an accepted statistical analysis that allows you to carry alpha beyond primary but divide it up and still remain at 0.05 for 2-6. I am not certain but there should be. So what if you don’t need to cross a more narrow 0.01 and you don’t have to be right in the right sequence.

What if the original PFS is irrelevant. I will give an example. If disability is seen in a relapsing remitting disease, it is not called permanent or sustained immediately. They recheck in the future to confirm this. Usually this is before analysis, but can be post hoc too. They usually do sensitivity analysis and check by 3 or more methods, like lets say at 3 months or 6 months or forever more.

Put that in you brain and spin it round and round again.

What if the equation I posted in June of 2017 or 18 is close to correct as a reasonable estimate. Then mOS hits. What if carrying it out and instead doing proportional hazards type stuff makes it even more certain. What if rGBM hits. There is a lot to consider but new primary is a dead head lock in my opinion.