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Sunday, November 21, 2021 2:37:58 PM
Article: https://digitalcommons.usf.edu/etd/8972/?fbclid=IwAR0V6gtYi_5Bv_we8vuUg7H_6BwHwzsoQkkxS0qLQ3lbCXby4gpRHhxJr4Y
Pretty neat read about S1R activation and its effect on endothelial cells. Endothelial cells form a thin barrier which line all blood vessels and regulate metabolic exchanges (nitric oxide, sugar, water, waste, etc.) from within the bloodstream and the individual cells – much like how the blood brain barrier protects the brain from most toxins and regulates what comes in and out. Another similarity to the blood brain barrier is the endothelial cell’s ability to degrade and become ‘leaky’, which has several detriments to the cardiovascular system.
The researchers were able to find that S1R agonists maintained endothelial cell integrity, and “relaxed rat mesenteric lymphatic vessels”. Mesenteric lymphatic vessels are used for glucose metabolism. The functional status of lymphatic muscle and endothelial cells is an important factor that supports fluid and macromolecule exchange and immune cell trafficking through the body and is also crucial to the transport of lipids (fat) adsorbed in small intestine.
A peer review journal expanded upon the importance of vascular endothelium, “A growing list of conditions, including those commonly associated as risk factors for atherosclerosis such as hypertension, hypercholesterolemia, smoking, diabetes mellitus and heart failure are associated with diminished release of nitric oxide (NO) into the arterial wall either because of impaired synthesis or excessive oxidative degradation. The decreased production of NO in these pathological states cause serious problems in endothelial equilibrium and that is the reason why numerous therapies have been investigated to assess the possibility of reversing endothelial dysfunction by enhancing the release of nitric oxide from the endothelium.”
The above excerpt is important as it mentions diminished nitric oxide as a significant catalyst for hypertension, diabetes, heart failure, etc. When researchers tested S1R agonists in cultured lymphatic endothelial cells (petri dish), S1R prompted elevated levels of nitric oxide. It is unclear from the publication if S1R brought NO back to normal levels, but any addition to vascular homeostasis is surely welcomed and is supported further by Anavex’s preclinical/clinical data. I continue to be impressed by the vast array of clinical benefit derived from S1R elevation.
Some of Anavex’s publications supporting S1R as a cardiovascular solvent:
Anavex Life Sciences Announces Notice of Allowance for U.S. Patent Application ANAVEX®2-73
Anavex Life Sciences Reports Potential Normalization of Hypertension with ANAVEX®2-73
Anavex: Research Report Reveals Cardioprotective Action of Sigma-1 Receptor Agonists
(Shoutout to DG for the cool find)
Recent AVXL News
- Anavex Life Sciences to Present at the H.C. Wainwright 5th Annual Neuro Perspectives Virtual Conference • GlobeNewswire Inc. • 06/20/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 06/17/2024 11:30:10 AM
- Anavex Life Sciences Announces Expansion of Leadership Team • GlobeNewswire Inc. • 05/22/2024 11:30:00 AM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 05/17/2024 10:01:00 AM
- Anavex Life Sciences to Present at the H.C. Wainwright 2nd BioConnect Investor Conference at NASDAQ • GlobeNewswire Inc. • 05/14/2024 11:30:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) Urged to Join Class Action - Contact The Gross Law Firm to Learn More • PR Newswire (US) • 05/10/2024 09:45:00 AM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/09/2024 08:35:55 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/09/2024 12:00:30 PM
- Anavex Life Sciences Reports Fiscal 2024 Second Quarter Financial Results and Provides Business Update • GlobeNewswire Inc. • 05/09/2024 11:30:00 AM
- The Gross Law Firm Announces the Filing of a Securities Class Action on Behalf of Anavex Life Sciences Corporation(AVXL) Shareholders • PR Newswire (US) • 05/07/2024 09:45:00 AM
- Form DEFA14A - Additional definitive proxy soliciting materials and Rule 14(a)(12) material • Edgar (US Regulatory) • 05/06/2024 10:03:33 AM
- Anavex Life Sciences Corporation Sued for Securities Law Violations - Contact The Gross Law Firm Before May 13, 2024 to Discuss Your Rights - AVXL • PR Newswire (US) • 05/03/2024 09:45:00 AM
- Anavex Life Sciences to Announce Fiscal 2024 Second Quarter Financial Results on Thursday, May 9th, 2024 • GlobeNewswire Inc. • 05/02/2024 11:30:00 AM
- May 13, 2024 Deadline: Contact The Gross Law Firm to Join Class Action Suit Against AVXL • PR Newswire (US) • 04/26/2024 09:45:00 AM
- Contact The Gross Law Firm by May 13, 2024 Deadline to Join Class Action Against Anavex Life Sciences Corporation(AVXL) • PR Newswire (US) • 04/19/2024 09:45:00 AM
- The Gross Law Firm Reminds Shareholders of a Lead Plaintiff Deadline of May 13, 2024 in Anavex Life Sciences Lawsuit - AVXL • PR Newswire (US) • 04/16/2024 09:45:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/12/2024 09:45:00 AM
- Anavex Life Sciences to Present at the Noble Capital Markets Virtual Healthcare Equity Conference • GlobeNewswire Inc. • 04/11/2024 11:30:00 AM
- Class Action Filed Against Anavex Life Sciences Corporation (AVXL) - May 13, 2024 Deadline to Join - Contact The Gross Law Firm • PR Newswire (US) • 04/09/2024 09:45:00 AM
- Anavex Life Sciences Corporation Class Action: The Gross Law Firm Reminds Anavex Life Sciences Investors of the Pending Class Action Lawsuit with a Lead Plaintiff Deadline of May 13, 2024 - AVXL • PR Newswire (US) • 04/05/2024 09:45:00 AM
- Shareholders that lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 04/02/2024 09:45:00 AM
- Lost Money on Anavex Life Sciences Corporation(AVXL)? Join Class Action Suit Seeking Recovery - Contact The Gross Law Firm • PR Newswire (US) • 03/29/2024 09:45:00 AM
- Investors who lost money on Anavex Life Sciences Corporation(AVXL) should contact The Gross Law Firm about pending Class Action - AVXL • PR Newswire (US) • 03/26/2024 09:45:00 AM
- Anavex Life Sciences to Present at the 23rd Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 03/25/2024 11:30:00 AM
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