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Re: grass1973 post# 335223

Sunday, 11/07/2021 9:30:33 PM

Sunday, November 07, 2021 9:30:33 PM

Post# of 470529
I trust Dr. Christopher U. Missling MS PhD MBA.

The timeline is as stated below.

The timeline is related to the COVID pandemic and trials.

The FDA has asked for additional patients spread fairly evenly from 5 to 18 years of age inclusive for the EXCELLENCE trial.

> Top-line data AVATAR: Potentially pivotal Phase 2/3 adult RTT clinical trial – expected 2H 2021

> Top-line data Phase 1 ANAVEX®3-71 clinical trial – expected 2H 2021

> Top-line data EXCELLENCE: Potentially pivotal Phase 2/3 pediatric RTT clinical trial – expected 1H2022*

> Top-line data ANAVEX®2-73-AD-004: Potentially pivotal Phase 2b/3 AD clinical trial – expected 2H 2022

> Initiation of ANAVEX®2-73 imaging-focused Parkinson’s disease clinical trial – expected 2021

Pipeline expansion opportunities for ANAVEX®2-73

> Initiation of potentially pivotal Phase 2/3 Fragile X clinical trial – expected 2021

> Initiation of potentially pivotal Phase 2/3 clinical trial for the treatment of a new, rare disease indication – expected 2021

https://e1cd7807-443e-425e-9433-41548681800c.filesusr.com/ugd/73f698_021c7a1cb7a24d78b02dac05e7262ef7.pdf

Good luck and GOD bless,
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