NorthWest Biotherapeutics Inc (NWBO)

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Because of the danger of live streptococcal organisms, Coley continued his treatments using a heat-killed streptococcal organism combined with a second organism that we now call Serratia marcescens. This concoction became known as Coley's Toxin. By 1893, he had tried his toxin on ten patients, most of whom did well.8 By 1916, he had documented 80 more cases in a monograph. 9 By the end of his career, he had written over 150 papers on this subject and treated almost 1,000 cases. He mainly used his toxins on patients with inoperable bone and soft-tissue sarcomas, observing that this treatment was far less effective on other types of cancer such as melanomas and carcinomas. Beginning in 1899, Parke Davis & Company had begun to prepare the toxins so they were available for all physicians. They were widely used for the next 30 years.10 [Last decade of wide use was in the roaring 20s]

As a result of his widely used treatment, as well as the fact that he was publishing his work, Coley was much in the public eye. Early in his career he received small donations from the Rockefeller family to help with his research, and in 1902 he arranged a large grant from the Huntington family that supported him and other cancer researchers. This endowment was the first in the United States designated specifically to study cancer….. - NIH