Thursday, October 28, 2021 9:56:36 PM
Blarcamesine works way beyond sigma-1.
Steady_T, you are right. To keep complicated (some would say, “tricky”) things simple, I stay focused on blarcamesine’s activation of the sigma-1 receptor protein. That, alone, makes both blarcamesine and Anavex Life Sciences Corp winners.
But you are correct. The story is much larger than just the sigma-1 receptor. There are “muscarinic” receptors, very different (in function) from the sigma-1 receptor. Propitious activation of muscarinic receptors by blarcamesine produces a diversity of favorable processes and outcomes; for which many remain to be discovered or utilized.
Blarcamesine. Bigger and better than anything on any pharmacy shelf, working so favorably in a diversity of ways, against a wide diversity of diseases and conditions. Until demonstrated in proper human clinical trials, a story (or molecule) too good to be true.
Check back on this in late 2022. Trial results will be definitive.
Then, on out, blarcamesine and Anavex 3-71 will be eagerly tested for a broad range of human (and animal) health problems. 2022 will close with only the first chapter in the Anavex story. Many after that; including muscarinic receptor applications.
You might want to add that 2-73 is a muscaric receptor agonist in addition to being a Sigma-1 agonist.
But you are correct. The story is much larger than just the sigma-1 receptor. There are “muscarinic” receptors, very different (in function) from the sigma-1 receptor. Propitious activation of muscarinic receptors by blarcamesine produces a diversity of favorable processes and outcomes; for which many remain to be discovered or utilized.
Blarcamesine. Bigger and better than anything on any pharmacy shelf, working so favorably in a diversity of ways, against a wide diversity of diseases and conditions. Until demonstrated in proper human clinical trials, a story (or molecule) too good to be true.
Check back on this in late 2022. Trial results will be definitive.
Then, on out, blarcamesine and Anavex 3-71 will be eagerly tested for a broad range of human (and animal) health problems. 2022 will close with only the first chapter in the Anavex story. Many after that; including muscarinic receptor applications.
Recent AVXL News
- Form 8-K - Current report • Edgar (US Regulatory) • 05/22/2026 12:15:26 PM
- Anavex Life Sciences Receives Expected Nasdaq Delinquency Notification • GlobeNewswire Inc. • 05/22/2026 12:00:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/15/2026 08:15:25 PM
- Form 3 - Initial statement of beneficial ownership of securities • Edgar (US Regulatory) • 05/14/2026 08:15:30 PM
- Form NT 10-Q - Notification of inability to timely file Form 10-Q or 10-QSB • Edgar (US Regulatory) • 05/11/2026 08:30:22 PM
- CEO Transition and Delayed SEC Filing Put Anavex (AVXL) Leadership Changes in Focus • IH Market News • 05/06/2026 02:52:36 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 05/06/2026 11:04:59 AM
- Anavex Life Sciences Board of Directors Appoints Former Senior Vice President of Clinical Development Terrie Kellmeyer, PhD, as Interim Chief Executive Officer • GlobeNewswire Inc. • 05/06/2026 11:00:00 AM
- Form 3 - Initial statement of beneficial ownership of securities • Edgar (US Regulatory) • 05/01/2026 11:18:47 PM
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- Anavex Life Sciences to Present at the 25th Annual Needham Virtual Healthcare Conference • GlobeNewswire Inc. • 04/07/2026 11:30:00 AM
- Anavex withdraws EU approval filing for Alzheimer’s therapy • IH Market News • 03/30/2026 12:39:26 PM
- Anavex Life Sciences Provides Comprehensive Regulatory Update • GlobeNewswire Inc. • 03/30/2026 11:30:00 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 03/25/2026 08:06:00 PM
- Anavex withdraws EU marketing application for Alzheimer’s therapy blarcamesine • IH Market News • 03/25/2026 02:06:58 PM
- Anavex Life Sciences Provides Update on Regulatory Review in the EU for Blarcamesine to Treat Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/25/2026 11:30:00 AM
- Anavex Life Sciences Presents New Data from its AD-004 Phase IIb/III Trial at AD/PD 2026 Conference Demonstrating Consistent Correlation Between the Treatment Effect of Oral Blarcamesine and Preservation of Brain Volume in Early Alzheimer’s Disease • GlobeNewswire Inc. • 03/23/2026 11:30:00 AM
- New Scientific Findings Highlight Hypothesis of Autophagy Failure as a Precursor of Amyloid Beta and Tau Pathology in Alzheimer’s Disease • GlobeNewswire Inc. • 03/20/2026 11:30:00 AM
- Anavex Life Sciences Presents Significant Treatment Effects of Blarcamesine in New Advanced Alpha-Synuclein Model of Parkinson’s Disease at AD/PD 2026 Conference • GlobeNewswire Inc. • 03/17/2026 11:30:00 AM
- Anavex Life Sciences to Present at the Citizens Life Sciences Conference • GlobeNewswire Inc. • 03/03/2026 12:30:00 PM
- Anavex Life Sciences to Present at the 46th TD Cowen Annual Health Care Conference • GlobeNewswire Inc. • 02/25/2026 12:30:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/25/2026 11:07:01 AM
- Anavex Life Sciences Appoints Seasoned Healthcare Leader to Board of Directors • GlobeNewswire Inc. • 02/23/2026 12:30:00 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 02/09/2026 09:40:27 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 02/09/2026 12:31:17 PM
