Anavex Life Sciences Corp (AVXL)

[RedShoulder]

Anavex has shown that A2-73 binds in a unique way to the S1-R, along with muscarinic receptors to reduce Amyloid Plagues.

However lowering the Amyloid Plaques is not the answer per numerous failed drug trails with adverse effects and no significant cognitive improvement with that approach.

"In the future, these and other interventions that thwart production of this most dangerous pool of axonal amyloid beta could be used in concert with early detection (through blood or imaging tests) to stop or slow the progression of AD."

Just another attempt to slow it down simply by reducing the Amyloid Plaques, I seriously doubt that approach can stop the disease progression.

“Our results suggest that the sigma-1 receptor might be a viable therapeutic target for reducing Abeta production, specifically in axons,”

Whereas A2-73 is going for stabilization and disease reversal by restoring homeostasis to the S1-R.

Simply the attempt to reduce the Amaloid Plaques has been a failure, including Biogen with no real significant cognitive improvement, adverse side effects, IV injection, and over priced.

The article was a FYI since a part of the subject involved the S1-R.