I can only explain it like this. Remember when George Bush ran against John Kerry? The Bush campaign hit hard immediately, Bush’s daughters gave John sunscreen that turned his skin a funky orange, they created an image of him in people’s minds as Herman Munster, they showed him blown by the winds of indecision while kite surfing, etc. Kerry never recovered from the juvenile insults in time to win the election. <br /> <br /> Once DCVax-l results come out, changing the primary endpoints will be attacked before it can be supported by the scientific community if a journal is not published near term. Children like AF will take years of brave trial patients’ efforts to create a better world for the rest of us, and flush them down the toilet to soothe his fragile ego and possibly any overlords, before this possibly new SOC can be scientifically introduced to the world. What a cruddy way to end 14 years of blood, sweat and tears, BUT it doesn’t have to be like that. Instead, a journal can explain things like synthetic controls, pseudo progression, the new definition of GBM and why GBM IDH wild type is more susceptible to DCVax-l. It might explain things like manufacturing expansion.