NorthWest Biotherapeutics Inc (NWBO)

[exwannabe]

Let me try again with a more complete answer.

The final step in the full maturation of the DC is the activation where they have been exposed to the antigen. Once activated, they will return home in order to transfer the antigen to T cells so they can attack the source.

With Direct, this last step has to take place in the tumor micro-enviroment which has many factors that make the process of recognizing the antigens difficult. Prins gave a good speech on this a while back if you recall.

Even if Direct was 100% identical to -L prior to activation, there is no reason to assume they would be able to recognize and activate in the actual tumor site as they can in a test tube.