Anavex Life Sciences Corp (AVXL)

[boi568]

Thank you for your kind words. Yes, sometime last year I posited that we really may be looking at a Sigma1 receptor disease -- I would now say a syndrome -- subject to multiple manifestations currently categorized as independent CNS diseases. That hypothesis is only getting stronger as trial results come in.

If an operational Sigma1 deficiency is at the root of multiple CNS diseases, those diseases are not independent of one another and, in fact, may be symptomatic rather than causative. The cause, the true pathology, may inhere in the underlying and failing basic cell biology. The thought that this can be addressed by a single small molecule seems Too Good To Be True.© Hopefully, it isn't.