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A couple of other things Missing said paraphrasing: Expect

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Investor2014   Tuesday, 08/10/21 02:09:00 PM
Re: RedShoulder post# 325171
Post # of 346163 
A couple of other things Missing said paraphrasing:

Expect to see strong dose response curve between the U.S. adult Rett and high dose AVATER study important for data submission.

Had only planned the PDD study as safety and PK information to decide whether a pivotal study would make sense, hence short 14 week study. Did not plan in advance to have 48 week OLE, but now very useful.

He mentioned that the PDD ADS-COG 70% correlation to AD along with the SIGMAR1 biomarker results clearly stronger than the signal that got Aduhelm approved.



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