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Tuesday, August 03, 2021 2:28:58 PM
Bristol Myers Seeks Redeeming Combination for Struggling Checkpoint Inhibitor
Published: Jul 27, 2021 By Vanessa Doctor, RN
https://www.biospace.com/article/bridgebio-bristol-myers-squibb-start-clinical-trial-to-treat-advanced-solid-tumors-with-kras-mutations/
Bristol Myers pulls lymphoma indication for Istodax after confirmatory trial falls flat
August 2, 2021 05:05 PM EDT Kyle Blankenship
https://endpts.com/bristol-myers-pulls-lymphoma-indication-for-istodax-after-confirmatory-trial-falls-flat/
Both of these BP’s have or had combo trials with DCVax set up, so they certainly know of Northwest Bio . . . . but then you probably knew that.
Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen Vaccine and Nivolumab in Treating Patients With Recurrent Glioblastoma
https://clinicaltrials.gov/ct2/show/NCT03014804?term=NCT03014804
Pembrolizumab and a Vaccine (ATL-DC) for the Treatment of Surgically Accessible Recurrent Glioblastoma
https://clinicaltrials.gov/ct2/show/NCT04201873?term=NCT04201873
And Merck exec’s have said that they are particularly interested in immunotherapies which show efficacy as a monotherapy . . . .
Drugmakers struggle to find immunotherapy combinations for cancer
David Crow in New York MAY 30, 2018
Roger Perlmutter, Merck’s top scientist, said the company would focus its future efforts on combinations where each of the drugs has been proven to work separately as a “monotherapy” before testing them together. “I’d prefer to combine mechanisms where both parts of the combination have activity by themselves,” he said.
https://www.ft.com/content/d39afa5e-6066-11e8-9334-2218e7146b04
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