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Re: La Flaca post# 322845

Tuesday, 07/27/2021 12:41:57 PM

Tuesday, July 27, 2021 12:41:57 PM

Post# of 462332
I’ll bet against your hedge.

If A-273 is already approved for Rett and possibly PDD with no serious side effects among all trials…,.

Didn’t Missling attend a conference about basket trials/master protocols?

A Basket Trial involves a single investigational drug or drug combination that is studied across multiple
cancer populations defined by disease stage, histology, number of prior therapies, genetic or other
biomarkers, or demographic characteristics. It is usually designed as a single-arm, activity-estimating
trial with overall response rate as the primary endpoint. A strong response signal seen in a sub-study
may allow for expansion to generate data that could potentially support a marketing approval.

https://www.fda.gov/media/125556/download
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