Saturday, July 24, 2021 1:37:37 PM
https://nwbio.com/program-update-presentation-by-dr-marnix-bosch-at-asco-2019/
The Flaskworks’ system doesn’t eliminate the need for a cleanroom, they will likely be installed in a C-class cleanroom, which is still over 5 times cheaper to operate than a B-class cleanroom. The current Flaskworks’ MicroDen system is designed to be operated inside a conventional incubator, which may be required to control some environmental conditions. The patents state this, and the published study from Northeastern University showed pictures of the system placed inside an incubator.
And by the way, it’s common to have bench-top manufacturing stations set up in a cleanroom, even Kite’s commercial CAR-T manufacturing plant in El Segundo has hundreds of automated systems similar to this:
Large-scale cell manufacturing – The CliniMACS Cell Factory
As far as what the next evolution of an industrialized manufacturing process could potentially look like for DCVax, there is an example here:
https://www.invetechgroup.com/services/manufacturing-automation-for-cell-therapies/
I doubt the Flaskworks’ system will be deployed at hospitals, but there are a couple companies that have completely closed and automated systems that are capable of manufacturing multiple types of cell therapies that could potentially be produced in a large hospital’s lab in the future. One is Lonza’s Cocoon system shown here:
https://www.biopharma-reporter.com/Article/2020/03/10/Lonza-partners-with-three-institutes-on-Cocoon-system
and the other is the Cell Shuttle system from Cellares. shown here:
https://www.fiercepharma.com/manufacturing/cellares-welcomes-poseida-aboard-cell-shuttle-as-it-closes-out-early-access-program
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