Anavex Life Sciences Corp (AVXL)

[Gator328]

I remember the Mudcats. I think they were playing AA ball. Glenn Davis was a solid player. He grew up not too far down the road in North Florida. I'm glad to hear he's doing well over there, his brief stint in GA must have made a wonderful impression if he's still got connections to the city.

You make a great point about AVXL being seen as more of a Rett stock than an Alzheimer's stock, which. is interesting because I don't think anyone on this board invested initially because of its interest in Rett syndrome. To me, at least, this has always been Alzheimer's-related and any other indications are a pleasant bonus.

I've been critical of Dr. Missling in the past, but I do applaud his decision to focus on an immediate, unmet need to create revenue -- Rett is significantly more likely to be approved quickly than Alzheimer's and I think the plan all along has been to use Rett to get the priority review voucher, which will then be used to speed up the FDA decision for Alzheimer's assuming the P3 readout hits all the endpoints. That is probably worth more than the $100 million or so he'd fetch selling it on the open market. With Biogen's drug having its own set of safety and efficacy issues, the opportunity to strike has never been better for Anavex.

I used to be primarily concerned that A273 won't have good P3 results. It's still possible, but my concern now is whether a competitor is able to sway the FDA into accelerated approval. If the Biogen approval showed us anything, being first is better than being better. Dr. Missling hopefully knows this and Rett approval will indirectly provide a catapult for Alzheimer's that puts us over the finishing line first.

We'll see...