NorthWest Biotherapeutics Inc (NWBO)

[hyperopia]

I'm not aware of anything to suggest that L is less effective with other high grade gliomas. It's just that there hasn't been a formal trial.

I agree that L may be effective with other high-grade gliomas. (the small phase I trial extended survival in some patients) You probably know that UCLA has been running an open label, phase II trial with various adjuvant combinations for malignant gliomas [anaplastic astrocytoma (AA), anaplastic astro-oligodendroglioma (AO)], as well as glioblastoma. I think Dr. Liau and others at UCLA have a pretty good idea who responds to DCVAx, and are looking at adjuvant and checkpoint combinations in an attempt to expand effectiveness in others who are less responsive.

A Phase II Clinical Trial Evaluating Autologous Dendritic Cells Pulsed With Tumor Lysate Antigen +/- Toll-like Receptor Agonists for the Treatment of Malignant Glioma

https://clinicaltrials.gov/ct2/show/NCT01204684