Excellent foresite dadofmarcandmax. (For those that don't know it, dadofmarcandmax is a certified epileptologist with his own practice)
Check out his comment below that was posted 5 years ago...and is now proving to be spot on!
dadofmarcmax Saturday, 09/24/16 10:37:48 AM
Re: None 0
Post # of 320864
Theorizing Neurodegeneration
"What causes cortical/subcortical network disruption? In my view, chronic neuroinflammation and the futile cycle of further degeneration caused by more progressive neuroinflammation. Once the neuroinflammatory cascade begins, in essence, it induces further neuroinflammation – a self-fulfilling prophecy, in my view. Targeting the herald steps in the chronic neuroinflammatory cascade, in theory, should be the approach researchers take to solve the mystery of neurodegenerative disorders.
Bashers love to point out how mice studies are insignificant [Gosh, how many times have we heard that? LOL], but when you think about evolution – where mammals share essentially similar tissues/nerves/systems and pathophysiological processes – preclinical data to suggest a drug may stop chronic neuroinflammation means a lot. The same pathophysiological processes exist in humans and further study in humans is worth investigating if there is evidence towards efficacy in preclinical murine models. Mouse models do mean something!
We are still in the beginning stages of understanding neuroinflammation and the disorders associated with this pathophysiological process, despite our relatively “long” time invested in Anavex. I reiterate that time and patience are key if you are comfortable about your investment hypothesis on this speculative, microcap biotech. Patience is a virtue! Have a great Saturday everyone!"
