Charlotte's Web Holdings Inc (CWBHF): "Co-administration of cannabidiol and ke...

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Charlotte's Web Holdings Inc (CWBHF)

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Monday, 06/28/2021 12:33:04 PM

Monday, June 28, 2021 12:33:04 PM

"Co-administration of cannabidiol and ketamine induces antidepressant-like effects devoid of hyperlocomotor side-effects":
19 June 2021

Highlights
-Both cannabidiol and ketamine promote antidepressant-like effect dependent on AMPA receptor activation.

-Pre-administration of cannabidiol did not induce effects per se in the open field test but prevented ketamine-induced hyperlocomotion.

-Cannabidiol prevented ketamine-induced hyperlocomotion while preserving its antidepressant effect.

-Cannabidiol holds potential therapeutic benefit as add-on therapy to ketamine to prevent its side-effects.

https://www.sciencedirect.com/science/article/pii/S0028390821002343

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