Anavex Life Sciences Corp (AVXL)

[wildcard235]

A273 increases sigma-1 receptors, in addition to activating them! People with Alzheimer's lose sigma-1 receptors as they age. This sounds to me like yet another very positive mechanism of action.

"ANAVEX®2-73 treatment resulted in increases in the mRNA expression of SIGMAR1, the gene coding for the receptor targeted by ANAVEX®2-73, which correlated with clinical efficacy as measured by both primary efficacy endpoints (ITT population), namely RSBQ (p = 0.035) and CGI-I (p = 0.029)."