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georgejjl

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georgejjl

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Saturday, 06/12/2021 4:31:00 PM

Saturday, June 12, 2021 4:31:00 PM

Post# of 458205
Anavex 3-71 (formerly known as AF710b)

The effects of AF710B at low concentrations in vitro against neurodegeneration, oxidative stress, Abeta, Tau-phosphorylation and GSK-3beta activation translate into down-regulation of the apoptotic protein Bax and mitochondrial dysfunction, up-regulation of anti-apoptotic Bcl2. AF710B has an exceptional pharmacology being an excellent cognitive enhancer



The unmatched potency of AF710B on cognition and on amyloid and tau pathologies, combined with its beneficial effects on inflammation and mitochondrial dysfunctions, indicates extensive therapeutic advantages for AF710B in AD and other protein-aggregation related diseases vs. a plethora of experimental and licensed treatments.



https://www.weizmann.ac.il/neurobiology/small-molecules-against-alzheimer%E2%80%99s-disease-ad-hallmarks-and-novel-therapeutic-targets

Good luck and GOD bless,
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