Most scientists want a complete trial to see, not partial-not even statistically significant since the number of patients is very small- results. <br /> Even if its for Rett, Parkinson's or anything. <br /> I think that their opinion on sigma-1's antioxidative stress properties, autophagy, mitochondrial or any other effect are theories not facts. <br /> Something like the vitamin mania that many people (even scientists) believed in the past that actually does not offer much to health improvement something that we know now. <br /> If one day we see complete statistically significant results then they will <br /> start changing their mind that there exists alternative ways to improve <br /> therapeutic options on these devastating diseases.