Amarin Corp Plc (AMRN)

[iryokabu]

Kiwi, I don't have any comment on EPA/AA ratio other than the following quote.

increased circulating EPA/arachidonic acid (AA) ratio (which may be indicative of cardiovascular benefit because high EPA:AA ratios are associated with decreased proinflammatory and pro-aggregatory mediators, whereas low EPA:AA ratios are associated with cardiovascular events including venous thromboembolisms, major adverse limb effects and increased mortality in patients hospitalized for decompensated heart failure)

EPA/AA ratio or Omega-3/Omega-6 ratio does not explain why EPA level was not associated with cardiovascular disease in STRENGTH trial. EPA/DHA ratio might be the key.