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Re: Nick119 post# 378977

Tuesday, 05/18/2021 10:49:19 PM

Tuesday, May 18, 2021 10:49:19 PM

Post# of 719500
Thank you Nick119, i was glad to see the slide below because Dr. Linda Liau basically telegraphed and laid out how the the DCVax-L clinical trial data, and revised Primary Endpoint in the revised SAP will be analyzed.

According to the revised SAP, the new Primary Endpoint is as follows:

compare overall survival (OS) between patients randomized to DCVax-L and control patients from comparable, contemporaneous trials who received standard of care therapy only, in patients with newly diagnosed glioblastoma. This endpoint will be assessed using 3 different analyses



Because of Dr. Liau's slide tonight, now we know what the 3 different analyses are:

Analysis 1: Cox Proportional Harzards

Analysis 2: Conditional Survival

Analysis 3: Subgroups, Cox PH



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