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Re: Bill B post# 340035

Monday, 05/17/2021 2:38:03 PM

Monday, May 17, 2021 2:38:03 PM

Post# of 425965
It's not just EPA levels, it's how you get there. All tertiles of TG levels in REDUCE-IT showed consistent RRR in MACE. In the highest tertiles in STRENGTH (which BTW were way below what was achieved in REDUCE-IT), showed no benefit. WHY?

1. DHA blunted the normally positive effects of EPA

2. Perhaps there were issues with the packaging and preparation of the active ingredients that caused oxidation and contamination.
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