Amarin Corp Plc (AMRN)

[Pharmacydude]

MNB
I agree that there was little interest in the prepare it presentation in February and there was also very little interest in the cardioLink-9 trial in Toronto in December. Things have changed. In February they announced that of the 1500 patients who were high risk healthcare professionals or family members of Covid positive patients that only 8% tested positive after two months. This was blinded data of both groups. At the time it was thought there was prepare-it 2 with an additional 500 patients who were Covid positive ambulatory outpatients. It now appears that both prepare-it one and prepare-it 2 each have 2000 patients in each trial. The Toronto trial was a phase 2 biomarker trial which had very encouraging data but only 100 pts. Argentina is running a trial of 2000 such patients. The data from these 4000 patients (combined) will give strong data (neutral or positive). IMHO the chances of stat sig efficacy in reducing the severity and duration of COVID are good. I have studied the pharmacology more intensely than any other topic in my life. The science seems very encouraging. I have had several Pt’s put on V as well as myself and the benefits have been obvious. The pathology of Covid is becoming more clear and everything pointing to an imbalance in the immune system with the inflammatory process spiralling out of control. Vascepa appears to restore balance to the immune system and reduce the exaggerated inflammatory response. There have been a couple positive Colchicine Trials recently and they have a similar mechanism of action in reducing the inflammatory response. The same people running the Argentina trial just completed a large colchicine trial and they certainly appeared to be celebrating (awaiting publication of results). Prepare-it 1 was for prevention of infection. Prepare-it 2 was to reduce the severity and duration of Covid positive outpatients. Colchicine was for inpatient severely ill. Three different patient populations and so positive Colchicine results will not wreck positive Vascepa results. If results are positive there will be supply problems. Also, positive Covid results SUGGEST it would work in other illnesses as well such as influenza, sepsis and other inflammatory conditions.
Here is a link to a document where I try and explain the science. https://docs.google.com/file/d/13dd7yIWqfdk0FlwUKRH32DJs3zAhe8zh/edit?usp=docslist_api&filetype=msword
Here is a short video where I explain with audio : https://drive.google.com/file/d/1EzskElGTt12lxXBudlgDF3SVWoB9R9pb/view?usp=drivesdk