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>>> VistaGen’s PH10 Nasal Spray Demonstrates Different Mechanism of Action from Benzodiazepines in Preclinical Study


VistaGen Therapeutics, Inc.

March 11, 2021


https://finance.yahoo.com/news/vistagen-ph10-nasal-spray-demonstrates-133000308.html


PH10 may have stand-alone potential to displace current oral antidepressants in the drug treatment paradigm for depression disorders


SOUTH SAN FRANCISCO, Calif., March 11, 2021 (GLOBE NEWSWIRE) -- VistaGen Therapeutics, Inc. (NASDAQ: VTGN), a biopharmaceutical company committed to developing and commercializing a new generation of medicines with the potential to go beyond the current standard of care for anxiety, depression and other central nervous system (CNS) disorders, today announced preclinical data demonstrating that the potential mechanism of action of PH10, its Phase 2 investigational pherine nasal spray with potential as a rapid-onset, stand-alone treatment for major depressive disorder (MDD), does not involve direct activation of GABA-A receptors, in distinct contrast to the mechanism of action of benzodiazepines, which act as direct positive modulators of GABA-A receptors. Instead, PH10 is designed to engage receptors in nasal chemosensory neurons which in turn regulate neurons in the limbic amygdala that release excitatory neurotransmitters producing rapid-onset antidepressant effects.

"These preclinical data suggest that PH10's mechanism of action does not work through GABA-A receptors, unlike many other neurosteroids, suggesting it may not have benzodiazepine-like side effects, such as sedation and cognitive impairment, or abuse liability," stated Mark Smith, MD, PhD, Chief Medical Officer of VistaGen. “Using in vitro patch clamp electrophysiology, PH10 had no agonist or antagonist effects on GABA receptors. While PH10 may regulate endogenous GABA circuits in the brain, it does not appear to directly bind to or modulate GABA receptors at concentrations of less than 10 micromolar, which differentiates its mechanism of action from that of benzodiazepines.”

In September 2020, the U.S. Food and Drug Administration (FDA) released a Drug Safety Communication (DSC) detailing the risks associated with use of benzodiazepines. According to the FDA’s communication, 92 million benzodiazepine prescriptions were filled in 2019. The DSC detailed safety concerns regarding the serious risks of abuse, addiction, physical dependence, and withdrawal reactions linked to long-term use of benzodiazepines, and the FDA announced that it is requiring an updated Boxed Warning, the FDA’s most prominent type of safety warning, for all benzodiazepine medications.

According to the World Health Organization, MDD affects more than 264 million adults globally. In the U.S., MDD is one of the most common mental health disorders, with over 17 million adults having experienced at least one major depressive episode within the most recent year (2017) reported by the U.S. National Institute of Mental Health. For some individuals, MDD can result in severe impairments that interfere with or limit one’s ability to carry out major life activities and can have significant emotional, functional, and economic impact on those who suffer from the disorder as well as their loved ones.

The current most commonly prescribed oral antidepressants are selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). SSRIs are intended to increase the amount of available serotonin by inhibiting the reuptake of serotonin in the brain, preventing nerve cells from reabsorbing serotonin and reducing the levels in the brain. SNRIs similarly are intended to inhibit the reuptake of serotonin and another neurotransmitter, norepinephrine, and increase the available amounts of each in the brain. While these medications can certainly be effective in the right context, they are associated with slow onset of action, numerous side effects and limited therapeutic benefits, often challenging for medical professionals to identify the right drug or combination of drugs for particular individuals.

Recent studies have shown that there has been an exacerbation of existing depression symptoms, with U.S. adults showing three times as many symptoms of depression during the COVID-19 pandemic, creating a critical need for new and differentiated alternatives for treatment of MDD. PH10 may have the potential to displace existing SSRIs and SNRIs as a stand-alone alternative in the drug treatment paradigm for depression disorders.

PH10 is a new generation antidepressant with a mechanism of action that is designed to be fundamentally different from all current FDA-approved antidepressants. After intranasal administration, a non-systemic microgram-level dose of PH10 binds to nasal chemosensory receptors that, in turn, activate key neural circuits in the brain that can lead to rapid-onset antidepressant effects, but without the psychological side effects or safety concerns that may be caused by rapid-onset ketamine-based therapy, including both intravenous ketamine and esketamine nasal spray, or the side effects and safety concerns of current oral antidepressants that may take many weeks to become effective.

About PH10

PH10 is a Phase 2 investigational pherine nasal spray designed to have rapid-onset effects and therapeutic potential in several neuropsychiatric indications involving depression. Self-administered in microgram-level doses, PH10 does not require systemic uptake and distribution to produce rapid-onset antidepressant effects. Following completion of a successful exploratory Phase 2A clinical study, VistaGen is preparing for a planned PH10 for a Phase 2B clinical study in the U.S. as a stand-alone treatment of MDD. With its rapid-onset pharmacology, lack of systemic exposure at clinical doses administered to-date and favorable safety results observed in all clinical studies to date, VistaGen believes PH10 has potential to be a new stand-alone treatment for several depression disorders.

About VistaGen

VistaGen Therapeutics is a biopharmaceutical company committed to developing and commercializing innovative medicines with the potential to go beyond the current standard of care for anxiety, depression, and other CNS disorders. Each of VistaGen’s three drug candidates has a differentiated potential mechanism of action, has been well-tolerated in all clinical studies to date and has therapeutic potential in multiple CNS markets. For more information, please visit www.vistagen.com and connect with VistaGen on Twitter, LinkedIn, and Facebook.

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