NorthWest Biotherapeutics Inc (NWBO)

[biosectinvestor]

For the same reason, this happens over and over again in history in many fields of endeavor. The first and easiest example given is usually David and Goliath.

And sometimes you see examples like the Wright Brothers vs Samuel Pierpont Langley, https://blogs.scientificamerican.com/observations/why-did-the-wright-brothers-succeed-when-others-failed/

Dr. Liau, and Prins seem to have been determined and are certainly well qualified for the task. And studying why others failed, is often the secret to success. Success often requires many failures leading to success. But those failures don't have to be your own failures.

And they are not the first to succeed, they could see who had succeeded, who didn't and what they did that led to their failure.

I personally have not studied every failure. Did they thnk one shot was enough, or one shot in an arm or directly into the tumor? Had they gotten the correct cells at the correct stage to do what they wanted the cell to do? Did they understand how antigens are picked up and what the state of the tumor itself should be for that to happen, whether outside of the body or inside of the body? What did they do to validate their treatment before trying it on humans or to manufacture it?

And what seem to be key issues, how did they understand the key ingredient, the autologous cells that they were extracting. Those cells have a complex life's journey where they do different things. Did they understand those details fully?

Much progress on cell therapies and cell programming has occurred in these last 2 decades. We've learned to take an adult blood cell, turn it into an embryonic like cell, and then into any cell in the human body, as if it is a baby cell. All of the science of that is studied and well known today in the field of cell therapy, and was being published over these last 2 decades or so.

We've learned to reprogram cells and how delicate the various states are to getting them to do one thing or another.

And, from decades and decades ago, we've studied how different factors, stimulants to the immune system, can help even to fight cancer. Did the others add those additional stimulants to their DC treatments?

There are billions of ways to do the same thing this complex, differently, and probably more than that.

So I know people want to ask that question, but really, often that is not the correct question... Why NWBO and not someone else? Why not? What did they have that was the secret to their success? I am sure that will be the main question people ask if and once DCVax is validated. I think they had a number of factors, and sometimes that is just fate that those elements all come together. Sometimes it is just that the key people just wanted to succeed that much more than others who tried, and they kept at it until they did succeed.

The link to the rest of this article is above:

Why
Did the Wright Brothers Succeed When Others Failed?
They weren't trained as engineers—but they were raised to have an insatiable intellectual curiosity

That two bicycle salesmen from Dayton, Ohio, were the first people to fly is as astonishing today as it was over a century ago, when the Wright brothers soared above slack-jawed crowds at public exhibitions in the United States and France. For a brief period, the world was united in wonder. The Wrights’ accomplishment is worth revisiting because it challenges the 21st-century conviction that aspiring young engineers should focus narrowly on STEM disciplines in college, and that courses in the arts and humanities are not as important as those in math and science. If the Wright brothers were alive today, they might warn us that pedagogical dogmas like these prevent us from cultivating engineers of the extraordinary type that they were.

Neither Wilbur nor Orville Wright majored in a STEM discipline. In fact, neither brother went to college and neither had any formal technical training. The Wright Flyer cost the brothers less than $1,000 (about $28,000 in today’s dollars) to construct, which they earned through profits from their bicycle business. The first prototype of the Wright Flyer flew 852 feet, and with modifications it eventually flew in excess of 40 miles. Not bad for two working class dreamers from Dayton with no engineering education, no internet access and no university laboratories or libraries.

At the same time that the Wrights were designing and testing their successful flying machine, Samuel Langley, a university professor and secretary of the Smithsonian Institution, was also designing his. Langley spent $70,000 (about $2 million today) on his “aerodrome,” which was mostly funded by a grant from the U.S. War Department. On its maiden flight, Langley’s aerodrome plunged into the Potomac River while attempting take off.