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Tuesday, February 23, 2021 1:02:43 AM
Lightrock:
Concerning response rate: One thing we have all observed in the past few years is the relation between certain genes or protiens and the effectiveness of cancer drugs. Could this account for a positive response rate by a subset of the test arm?
I asked this question to Gavin on February 9, 2021:
Many cancer treatments are specific to whether the cancer expresses a certain gene or mutation.
Are the enrollees going to be tested to see if there is a correlation between the survivability and any genetic markers or mutations?
The response:
Yes, we will be looking into this as well.
So, I read this to mean that if you hypothetically have a 100% response rate with only some individuals the study results could contain data concerning the efficacy of MK compared with certain DNA markers. This might be another reason why the P3 trial results are delayed, no?
Perhaps the calculator should calculate the p value for any scenario. A new feature?
Cheers again from an even-later evening in Oregon.
Jim
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