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Re: xodcode post# 299709

Saturday, 02/20/2021 4:34:36 PM

Saturday, February 20, 2021 4:34:36 PM

Post# of 464604
AVXL vs SAVA pipeline. AVXL's extensive CNS pipeline, vs SAVA one trick pony that is down stream of Anavex's 2-73 and 3-71 which works upstream as a prevention of the problem before SAVA's drug is needed, making SAVA's drug redundant.

Anavex A2-73 pipeline is for Alzheimer's (2 years ahead of SAVA), Parkinson's Dementia, Parkinson's disease, Rett Syndrome, Fragile-X, Angleman's, and Infantile Spasms.

Anavex A3-71 pipeline is for Frontotemporal Dementia (FTD), and Neurodegenerative Diseases.

Anavex A1-41 pipeline is for Depression, Stroke, and Neurodegenerative Diseases.

Anavex 1066 pipeline is for Visceral Pain, and Acute Neuropathic pain

OTOH SAVA has simufilam for an Alzheimer treatment that works down stream of Anavex's 2-73 and 3-71 which works upstream as a prevention before SAVA's drug is needed, making SAVA's drug redundant. Plus AVXL's pivotal Alzheimer's trail starting soon in the first half of this year is two years ahead of SAVA's Alzheimer's program.

Multiply AVXL MC by 2 and AVXL will equal SAVA MC.

Comment: Difficult to rationalize that currently SAVA's MC is twice AVXL's based upon comparative pipelines. (SAVA and AVXL valuations need to adjust more equitably)



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