We had Shot #2 last Friday. Jane had a bit of a head ache on Saturday and said she felt "off" a bit. I was fine Sat morning but felt a bit fatigued later in the day. (good excuse to take a nap) At 71.5 years old, I guess that's not the worst day of my life. Sunday I felt back to normal.
I've heard Shot #1 works as a wake up call for one's immune system. When the serum is used with the second shot, our immune system recognized it and fires up a bit in reaction to the foreign materials. So, even with the same serum for both shots, the reaction is slightly greater with #2.
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