Anavex Life Sciences Corp (AVXL)

[falconer66a]

Good Question

...are you saying/implying that faulty genes within an individual can or "may be" fixed by A2-73 due to the process?

Thank you. Very good question.

No, blarcamesine will not be able to fix inherited genetic defects, where, at birth, a gene for a particular trait has an error, producing any one of the many genetic diseases in humans. Those will have to be fixed (if they can) by CRISPR-Cas9 genome editing, genetic engineering, as it were.

But a lot of genetic errors occur because the proper, healthful sequence of DNA nucleotides (the A's, T's, G's, and C's) don't get properly translated, by the process of transcription, into good proteins. That's what blarcamesine can do.

Many transcription-error diseases occur with age. I have one of those myself, a mild form of hereditary spastic paraplegia. Until I was in my mid 60s I had no problems. But then, slowly, my legs started to stiffen. My adductor muscles remained tight, couldn't be relaxed. Today, I have to walk with a walker. The genes for the production of gamma-aminobutyric acid (GABA) in the long motor neurons controlling the adductor muscles in my legs don't get translated into sufficient GABA. That causes the hyperexcitability in those muscles; always tight. For me, blarcamesine will fix this. My particular translation, transcription error will be fixed. It occurred as I aged, common for many diseases.