Amarin Corp Plc (AMRN)

[lettruthringout]

Association of atherogenic dyslipidaemia with all-cause mortality

There were 3,602 deaths over a follow-up 7.42?±?2.05 years (31.0?×?1000 person-years). In the unadjusted analyses, the highest TG:HDL (but not triglyceride) and the lowest HDL cholesterol quartile were associated with increased death rate and mortality risk. When sequentially adjusting for confounders, including total, LDL, or non-HDL cholesterol and lipid-lowering treatment, mortality risk was significantly higher in the highest triglyceride (hazard ratio 1.167 [95% confidence interval 1.055–1.291], p?=?0.003) and TG:HDL (1.192 [1.082–1.314], p?<?0.0001) and the lowest HDL cholesterol (1.232 [1.117–1.360], p?<?0.0001) quartile, though the association of triglycerides and HDL cholesterol disappeared after further adjustment for each other. Interaction with gender was significant only for HDL cholesterol (p?=?0.0009). The relationship with death was stronger for triglycerides in males and HDL cholesterol in females, with these associations remaining significant even after adjustment for HDL cholesterol (1.161 [1.019–1.324], p?=?0.025, for the highest vs the lowest triglyceride quartile) and triglycerides (1.366 [1.176–1.587], p?<?0.0001, for the lowest vs the highest HDL cholesterol quartile).

https://cardiab.biomedcentral.com/articles/10.1186/s12933-021-01224-7