Aurinia Pharmaceuticals Inc (AUPH)

[moosedogger]

Jess, GSK and AUPH differ somewhat on CRR definition:

Pages 90 and 91 state:

Definitions in BLISS-LN trial: Complete Renal Response (CRR): ratio of urinary protein to creatinine of <0.5, eGFR no worse than 10% below pre-flare value or ≥90 ml/min/1.73 m2with no use of rescue therapy.


Definitions in AURORA trial: Complete Renal Response (CRR): Decrease in UPCR to ≤0.5mg in 2 consecutive, first morning void urine specimens, eGFR >60ml/min per 1.73 m2 or no decrease of ≥20% of baseline eGFR on 2
consecutive occasions, No use of rescue therapy and presence of sustained low-dose steroids


Not aware (yet) exactly what differentiates 'CR' from 'CRR', or if they're interchangeable or what.