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Thursday, 11/26/2020 3:30:10 PM

Thursday, November 26, 2020 3:30:10 PM

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Will blarcamesine be needed for human spaceflight?

A new study shows that humans in space have, among other chronic health problems, significant mitochondrial disfunction. Simply, in long-term low-gravity conditions, mitochondria fail to function properly. With that, all sorts of downstream health problems can ensue.

https://www.cell.com/cell/fulltext/S0092-8674(20)31461-6

So, a new Anavex study needs to send some mice to the International Space Station, where half will drink plain water; the other half water amended with an appropriate concentration of blarcamesine --- to see if the Anavex drug might prevent mitochondrial disfunction in space.

The drug's activation of the sigma-1 receptor protein, on earth, restores mitochondrial function. It might do that for humans, in space.
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