NorthWest Biotherapeutics Inc (NWBO)

[indialong]

"More generally, Chan et al. [6] compared published articles with protocols for 102 randomized trials approved by the Scientific-Ethical Committees for Copenhagen and Frederiksberg, Denmark in 1994–1995, and reported that 62% of the trials had at least one primary endpoint that had been changed, introduced, or omitted. Chan et al. [7] compared published articles with protocols for 48 randomized trials approved for funding by the Canadian Institutes of Health Research in 1990–1998, and reported that primary endpoints differed between protocols and publications in 40% of the trials. Given that changes to endpoints are so frequent, it's important to evaluate when such changes are appropriate and how they should be reported."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852589/