Anavex Life Sciences Corp (AVXL)

[jimmy_mcyoloswag]

My 2 cents FWIW:

The ryanodine receptor is a large target, many side effects to be expected. The evidence of this study indicates Alz effectiveness by addressing a phenomenon also seen in Alz. I would count this as second degree evidence, not direct. Twice removed, if you will.

At the same time this adds further evidence to my personal theory that dysfunction of mitochondrial and ER associated calcium homeostasis is a key player in neurodegenerative diseases.

Incidentally, S1r activation addresses this, specifically, elegantly and apparently by original function, on an as needed basis (think fire truck):

https://www.cell.com/cell/fulltext/S0092-8674(07)01099-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867407010999%3Fshowall%3Dtrue