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Re: Churchill54 post# 11221

Tuesday, 10/27/2020 9:36:29 PM

Tuesday, October 27, 2020 9:36:29 PM

Post# of 17547
I didn’t expect this PR and the potential here is huge. Anti-inflammatory and now indicating anti-viral. The combos and synergies here are immense if any of this pans out useful. Voclosporin cocktails ? What we know per PR Voclosporin inhibited covid at mega low levels.
“Calcineurin inhibitors (CNIs), like voclosporin, have been shown in prior in vitro studies to inhibit viral replication. The team at the LUMC demonstrated that voclosporin inhibited viral replication of SARS-CoV-2 at an 8-fold lower concentration than tacrolimus in vitro, while maintaining cell viability of infected cells. In contrast to voclosporin, tacrolimus did not show antiviral activity against SARS-CoV-2 in vitro at clinically relevant concentrations. “
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