Anavex Life Sciences Corp (AVXL)

[Doc328]

Significance is also a function of standard deviation. The three factors are n, effect and stdev. So a small sample can give a significant finding by having a large effect or having tighter stdev.

This is easy to test by plugging values into a calculator:

i.e 4,6,8,8,10,12 vs 8,9,10,11,12,13 has means 8 and 10.5 with p = 0.10
while 6,6,8,8,10,10 and 9,10,10,11,11,12 has same means 8 and 10.5 but p = .0144

So n is the same, difference in means (magnitude of effect) is the same but with a tighter group, the difference id significant

Regardless, it looks like we won't have more details for a while. CTAD (though mostly AD, other dementias also presented) is in 2 weeks but its probably too late for a late breaking session. Any peer reviewed article is many months away.