Nkarta Inc (NKTX)

[jondoeuk]

A CAR-NK cell product targeting MICA/B should overcome solid tumor escape from NKG2D-mediated mechanisms of recognition and killing.

A paper demonstrated that antibody targeting of the MICA/B a3 domains specifically prevents shedding and is able to restore NK cell-mediated immunity [1]. Additionally, cancers with B2M and JAK1 inactivating mutations which result in the loss of MHC Class I expression can be effectively targeted with a MICA/B a3 domain-specific antibody to restore NK cell-mediated immunity against solid tumours resistant to cytotoxic T-cells [2].

Refs:
1 https://science.sciencemag.org/content/359/6383/1537.full
2 https://cancerimmunolres.aacrjournals.org/content/8/6/769.long