In addition, make sure the knockouts are designed to try and overcome the TMEs.
Refs:
1 https://www.nature.com/articles/nature21405
2 https://www.sciencedirect.com/science/article/pii/S0065277615000310
3 https://www.nature.com/articles/leu2015247
4 https://www.nature.com/articles/nm.4241
5 https://www.pnas.org/content/106/41/17469
6 https://www.pnas.org/content/102/27/9571
7 https://www.nature.com/articles/nm.4478
8 https://cancerres.aacrjournals.org/content/80/16_Supplement/879
9 https://ashpublications.org/blood/article/132/8/804/39474/Preinfusion-polyfunctional-anti-CD19-chimeric
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