a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression
9/2020 Not tested in humans - animals only.
In summary, the results of the present study demonstrated that the combination treatment of cedrol and TMZ synergistically inhibited the growth of GBM cells via the induction of cell cycle arrest, cell apoptosis, and DNA damage response in vitro and in vivo. Cedrol enhanced TMZ-induced cell death by down-regulation of TMZ-resistant related proteins, including MGMT, CD133, and MDR1, and improved TMZ-induced liver damage. These findings provide a foundation for further study into cedrol as a potential agent in GBM therapy with TMZ. https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00580
Recall - our last report had 23 MGMT unmethylated ALIVE -
don't know if - Cedrol - could increase / enhance that number
Posted awhile ago Piperine
synergistically enhances the effect of temozolomide against temozolomide-resistant human glioma cell lines
Temozolomide (TMZ) is an alkylating chemotherapy agent used in the clinical treatment of glioblastoma multiforme (GBM) patients. Peppers
Piperine (PIP) is a naturally occurring pungent nitrogenous substance present in the fruits of peppers.
We investigated the anti-cancer efficacies of PIP alone and in combination with TMZ in GBM cellsusingparameters such as cell proliferation, cellular apoptosis,caspase-8/-9/-3 activities, cell cycle kinetics, wound-healing ability, and loss of mitochondrial membrane potential (MMP).
Treatment with PIP and alow concentration of PIP-TMZ,
----inhibited cell growth,
----similar to TMZ.PIP-TMZ promoted apoptosis by activation of caspase-8/-9/-3,
----MMP loss, and inhibition of in vitro wound-healing motility.
Reverse transcription polymerase chain reaction analysis showed significant inhibition of Cyclin-dependent kinases (CDK)4/6-cyclin D and CDK2-cyclin-E expression upon treatment with a low concentration PIP-TMZ, suggesting an S to G1 arrest.
Our findings provide insight into the apoptotic potential of the combination of a low concentration of PIP-TMZ, though further in vivo study will be needed for its validation. https://pubmed.ncbi.nlm.nih.gov/32693671/