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Re: wsbc post# 324120

Friday, 09/18/2020 6:12:33 AM

Friday, September 18, 2020 6:12:33 AM

Post# of 402865
I just realized I didn’t answer the question. For a simplified answer for what the molecule is that mimics a defensin peptide I went to Wiki: “... is an arylamide foldamer designed to replicate the amphiphilic properties of antimicrobial peptides while solving the problems encountered by peptide-based antimicrobials.”

Defensin peptide mimitics are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as helices and ß-sheets.

Arylamide foldamer: an aromatic ring molecule containing peptide bonds that folds on itself. “ They are artificial molecules that mimic the ability of proteins, nucleic acids, and polysaccharides to fold into well-defined conformations, such as helices and ß-sheets.”

Yes, Brilacidin is a non-peptide mimetic.

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