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jondoeuk

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jondoeuk

Re: jondoeuk post# 2

Friday, 09/11/2020 9:43:45 PM

Friday, September 11, 2020 9:43:45 PM

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At AACR the company showed that an optimised Cas9 gene editing system could successfully disrupt TGFbR2 and CISH. Knockout of the former made CAR-NK cells resistant to TGF-b mediated inhibition of cancer cell killing. For the latter KO CAR-NK cells had improved proliferation, survival, cytokine production and cancer cell killing. The findings showed that gene editing could be combined with CAR engineering to enhance NK cell function and resist the inhibitory tumour microenvironment https://www.nkartatx.com/file.cfm/75/docs/Nkarta_AACR_2020_gene_editing_891_20.pdf
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