NorthWest Biotherapeutics Inc (NWBO): How can you say they have not proved it...

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CherryTree1

Re: A deleted message

Saturday, 08/22/2020 6:57:07 PM

Saturday, August 22, 2020 6:57:07 PM

How can you say they have not proved it ???
Have you read the still blinded data paper? It is quite compelling.
Top 100 Patients

The top 100 patients in the trial (patients with longest survival times) can be viewed as one measure of a long tail of survival. The Kaplan-Meier (KM) derived interim overall survival (OS) data on these patients is as follows:

Median OS From Surgery 95% Confidence Interval
2017 data 40.4 months 35.5 – 46.5 months
2018 data 58.4 months 45.9 – 94.5 months
The survival of the top 100 patients does not appear to be fully explained by known prognostic factors. For example, only 8 of the 100 patients had the favorable status on 3 key prognostic factors combined: age <50 years, methylated MGMT gene status and full surgical removal of the tumor. The demographics of the top 100 patients are somewhat more favorable than those of the whole 331-patient ITT population in the trial, but are not greatly more favorable. The top 100 patients include more patients with methylated MGMT, but also include a substantial percentage of unmethylated patients.

https://nwbio.com/updated-interim-data-from-phase-3-trial-of-dcvax-l-for-glioblastoma/

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