NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

Thanks for providing all the links! But taking a quick look, I am a little dazed and confused. Maybe it will gel if I keep reading, but in the mean time, may I ask another related question: (Assuming the answer is yes):

"How many amino acids the TCR needs to interact with to notice the difference is may be as little as 1 and as many as the whole peptide chain."

So what size/length are the protein segments presented by the common cells for use in presenting possible mutations? Are they in that same 8 to 17 amino acid range? And are they long enough to display folding... hydrogen bonds, disulfide bonds...? Do they have shape? Are you saying that the T-Cells can detect shape, and not just sequence. Like an antibody would detect and mate with shape including electrostatic mapping?

I had always thought of the T-Cell detection of mutants strands as a straight sequence analysis or mating of some kind... linear.