NorthWest Biotherapeutics Inc (NWBO)

[longfellow95]

Hi Abeta. The thing about GBM tumors is that they are constantly morphing between the different cell types, especially as a result of treatment challenge, whether it be chemo or rad or anti-angiogenic (Bev). And although the shift is basically towards mes, it can also back-double if necessary.
It's why I don't really buy in to the 'DCVax works best with mesenchymal' thing.
Rather (for me), it's the only thing that works with all types.


Here's a quote:-

The team distinguished four distinct tumor cell types. Each type closely resembled different types of normal developing brain cells: neural progenitor cells, oligodendrocyte progenitor cells, astrocytes, and mesenchymal cells. The proportions of the different cell types varied according to the genetic defect driving the patient’s cancer (increased copies of PDGFRA, CDK4 or EGFR, or alterations of NF1). But every patient had all four tumor cell types.
More ominously, the four cell types could all change into each other. The study found that glioblastomas are highly “plastic” — their cell types readily morphing over time and when exposed to cancer treatments. When the researchers injected any of the four types of patient tumor cells into mice, they all formed tumors containing all four cell types.

-“This explains the failures of single-target drugs,” says Filbin. “The tumors can ‘become’ something else and escape our drug therapies — and it’s very easy for them.”

-As for glioblastoma, the new findings indicate a need for combination therapies that target all four tumor states at once.

https://discoveries.childrenshospital.org/glioblastoma-single-cell-sequencing/


I like to think that L is the only therapy that can target all four tumor states at once. Especially if the autologous whole tumor lysate (from which the L is made) has that full cell heterogeneity. And the tumor cannot mutate to escape, because L has all the bases covered.
That's my lay person way of understanding it.

And hopefully there is a simple key to achieve similar efficacy with unmeth also, if they can only find it.
(I don't think it will be using an ICI...)


Regards.