Amarin Corp Plc (AMRN)

[jessellivermore]

jf...

Its back to the old.."Reduces progression" issue..Stop for a moment and think what that term really means..It does not mean the plaque is going away or "evaporating".. Its just means the the arteries are getting worse but not as fast as without Vascepa..That probably is a good thing but it does not mean your gummed up arteries are now going to be clean and safe..Might mean if you start Vascepa in your forties you will be cutting your future risk.

VASCEPA's...main action has to be its anti inflammatory effects. And this goes to inflammation at the vessel wall and in the plaques...The idea is inflammation at the endothelial lumen interface and inflammation in the plaques themselves which bursts through the plaque cap and into the blood stream causing acute obstruction of the blood flood distal to event by platelet aggregation and other inflammatory effects..The events are so dangerous because they are so sudden.. Gradual occlusion of blood vessels can be tolerated if there is sufficient time to establish collateral circulation...Heart attacks and ischemic strokes are so deadly because there is no time to develop collateral circulation..

":>) JL