Intermittent dosing is interesting. I thought about intermittent dosing when I did research for my first post about the recent Seeking Alpha article, which mentions mTOR. Overwhelming evidence shows a primary role for TOR signaling in aging and CNS diseases are diseases of the aging. The SA article mentions this:
"...AD and PD are both associated with impaired autophagy, so stimulating autophagy flux is desirable. A2-73 activates autophagy by somehow increasing phosphorylation of the protein ULK1 at a serine amino acid located at position 555 (pS555). This is exciting because S555 phosphorylation of ULK1 can block age-related enhanced mTORC1-mediated ULK1 phosphorylation at S757 and subsequent autophagy downregulation."
The reason why I thought about the use of intermittent for AVXL 2-73 is because either the SA article and research mentioned mTORC1 as a target for the drug rapamycin. I did research on rapamycin. That drug is used to suppress the immune system so that organs transplanted will not be rejected by the body. Rapamycin has adverse side effects. Interestingly, intermittent dosing of rapamycin is used off label for anti-aging purposes. Some profess that if used intermittently rapamycin's side effects are minimal, and that "knocking down" the adverse consequences of mTor once a week results in the prevention of many problems that come about with aging. (My non-professional wording from reading quite a number of articles.)
I will write more about this later when I have time. I think intermittent dosing is interesting because some companies have been trying to produce a drug that has the same effect as rapamcyin on age related problems, but not the same side effects. Rapamycin, I think, will never be widely used for anti-aging or aging problems.
Of course, it seems that AVXL 2-73 is safe. If turning off mTor activity that creates many problems for us folks that are aging, it may be used safely - especially if it is used intermittently. If used intermittently, it too is less expensive even if the initial price of AVXL 2-73, if approved, is high.
Please excuse any typos, etc. I wrote this without checking it.
