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Re: biosectinvestor post# 293285

Thursday, 07/02/2020 3:58:31 PM

Thursday, July 02, 2020 3:58:31 PM

Post# of 731966

And then when you line up many other indicators, I think it just starts to look quite clear to me, again, just my opinion, but rationally, it starts to just add up, point-by-point-by-point.



biosectinvestor,

Watch Linda Liau's presentations of 2016 available here on the web:

http://www.westnsurg.org/pdfs/Presidential%20address%202016-Linda%20%20Liau.pdf

In both presentations Linda Liau pays much attention to one of her scientific papers finalized in the summer of 2015 and published in May 2016.
"TCR Sequencing Can Identify and Track Glioma-Infiltrating T Cells after DC Vaccination/Melody S. Hsu et al."

We showed that an increased estimated TIL content prior to therapy was associated with prolonged TTP and OS. All very long-term survivors in this trial had estimated TIL content in the top quartile. The correlations between estimated TIL content and TTP and OS suggest that estimated TIL content in the initial tumor specimen may be used to select patients for DC vaccination and may be applicable to other immunotherapies as well. In contrast, TIL content was not associated with survival in patients who were not treated with immunotherapy. Thus, our data suggest that the use of TCR sequencing to predict such survival indices may be directly relevant only for patients undergoing immunotherapy treatments such as DC vaccination.
https://cancerimmunolres.aacrjournals.org/content/4/5/412


The sentence in bold seems like a detail, but it might have been very important for the German authorities in the summer of 2015.
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