Amarin Corp Plc (AMRN)

[jessellivermore]

Kiwi...

Yes...But even in 2010 the most important consideration was that Systemic Inflammation (SI) might be the real culprit..For years cardiologists and lipidologists had viewed atherosclerosis as an accumulative process..Very similar to pipes that carried waste or sewage get clogged over time..

Evidence of the eicosanoid system..Was well known to medical scientist..but not widely known to MD clinicians..So there was (and still is) a wide separation between what PHD physiologist knew and what clinicians who treated the patients knew..

The key factor was the control of SI by cellular membrane receptors. Receptors which were present on every cell in the body except Red Blood cells.These receptors were effected only by active chemicals that presented the correct three dimensional structure..There active agents were "eicosanoids" arachidonic acid..Aspirin, NSAIDs and Cortical-steroids..EPA has the correct 3-D structure to interact with the membrane receptors DHA does not.

The early thinking that heart attacks and strokes were caused by sludge plugging up the arteries was caused by evidence the Aortas of 18 year olds killed in the Korean war showed cholesterol streaks..In clinical lipidology the sewer pipe clogging from accumulating cholesterol was pretty much the Gospel.."To the man who owns a hammer"..the world looks like a nail..Most of the lipidologists favored DHA overt EPA simply because DHA more effective than EPA at lowering Trigs..Which if you believed the orthodox theory would have made EPA less likely to lower CVD event risk..

Another fly in the ointment was although elevated trigs are most definitely a risk factor for CVD.. By a wicked twist of fate..Trig lowering does not always result in lowering CD event risk..Because elevated trigs are usually the result of elevated SI..And it is the elevated SI that is increasing the CVD event risk.

This is fairly convoluted and does not suggest anything at the time these patents were filed that anything was obvious or widely understood..

":>) JL